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2 edition of role of peptide in direct allorecognition in human transplantation found in the catalog.

role of peptide in direct allorecognition in human transplantation

Clive J. Pigott

role of peptide in direct allorecognition in human transplantation

by Clive J. Pigott

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Published by Oxford Brookes University in [Oxford] .
Written in English


Edition Notes

Thesis (Ph.D.) - Oxford Brookes University, Oxford, 2002.

Statementclive J. Pigott.
ContributionsOxford Brookes University.
The Physical Object
Paginationix, 195 leaves :
Number of Pages195
ID Numbers
Open LibraryOL20847421M

  Teleologically, it can be argued that direct allorecognition might have a dominant role in the early phase of the response after transplantation, Cited by:   ALLORECOGNITION n engl j med ;15 october 7, Direct, indirect and semi-direct pathways of allorecognition Curr Opin Organ Transplant. Aug; 13(4) T-Cell Activation and Differentiation *Danovitch, G. M. (). Handbook of kidney transplantation. Clin J Am Soc Nephrol –, November,

The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor by: -acute rejection: direct pathway of allorecognition-transfusion effect: indirect pathway of allorecognition When donor MHC: donor self-peptide complexes activate recipient T cells, _____. acute rejection of transplanted organs occurs. Barriers to using pig organs in human transplantation .

Transplantation is a unique immunological situation in which priming of recipient T cells with antigen can occur by three distinct pathways. Direct allorecognition is the interaction of recipient T cells by the T-cell receptor (TCR) with intact allogeneic MHC-peptide complexes presented by . In order to appreciate the role of HLA in transplantation, we must first consider the structural and functional aspects of HLA molecules. HLA antigens are controlled by a series of highly polymorphic genes on the short arm of chromosome 6, referred to as the human MHC (Figure 1).


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Role of peptide in direct allorecognition in human transplantation by Clive J. Pigott Download PDF EPUB FB2

Direct allorecognition. The direct pathway is the mechanism by which recipient T cells recognize determinants on intact donor major histocompatibility complex (MHC) molecule–peptide complexes displayed on the surface of transplanted cells (Fig. 1a) without the requirement forCited by: OCLC Number: Description: pages: illustrations ; 24 cm.

Contents: Synthetic peptides derived from human MHC Class I sequences delay allograft rejection in rodents and inhibit cell-mediated cytotoxicity In vivo and In vitro / M.-C. Cuturi [and others] --The role of polymorphic donor peptides in allograft recognition and rejection / J.W.

Fabre --The role of peptide specificity in. The role of peptide in direct allorecognition in human transplantation. (Thesis) Pigott CJ. Publisher: Oxford Brookes University [] Metadata Source: The British Library Type: Thesis.

Abstract. No abstract supplied. Menu. Formats. Abstract. EThOS. About. About Europe PMC Author: Pigott Cj. The role of peptide in direct allorecognition in human transplantation Author: Pigott, Clive J.

ISNI: Awarding Body: Oxford Brookes University Current Institution: Oxford Brookes University Date of Award: Availability of Full Text. The precise role of semi-direct allorecognition in transplantation rejection and tolerance remains to be fully elucidated. Conclusions The potent immune response elicited by the transplantation of foreign tissues has progressively been unraveled over recent by: The purpose of this study was to investigate indirect alloreactivity in the peripheral blood of long-term renal transplanted patients.

We evaluated the T cell proliferative response to a whole pool of donor cell-derived allopeptides, processed and presented by host antigen-presenting cells (APC), rather than to synthetic by: Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen via the indirect by: 7.

Abstract. Transplantation of organs and bone marrow is the therapy of choice for an increasing number of patients. The greatest problem encountered after transplantation of cells and tissue from a genetically different donor is that the immune system of the recipient recognizes the transplant as foreign and will try get rid of it in essentially the same way as the immune system deals with Cited by: 3.

Direct allorecognition refers to the recognition of MHC-peptide complexes on donor APCs directly by recipient T cells (51) which likely only play a role during acute graft rejection, as donor.

This chapter discusses the two pathways of allorecognition-direct and indirect-and suggests that the direct pathway plays a major role in the early weeks after transplantation and that the indirect pathway may contribute to the process of chronic rejection.

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for Cited by: during the transplantation process, supporting a role for the semi-direct pathway in rejection (19).

The human alloresponse measured in vitro involves CD4 and CD8 cells in both naive and memory T cell compartments (20, 21). Greater HLA mismatching would be expected to increase the diver-File Size: KB. the peptide binding groove, regardless of the specific pep‑ tide present in the allo‑MHC.[14] However, this view of the peptide‑independence of direct pathway allorecognition has been challenged recently.

[15,16] The key point is that in direct allorecognition, the host T cell [Figure 1] binds to the intact donor allo‑MHC/peptide Size: 1MB.

Roles of the six peptide-binding pockest of the HLA-A2 molecule in allorecognition by human cytotoxic T-cell clones February Proceedings of the National Academy of Sciences 90(2) Abstract: New insights into the mechanisms of allorecognition (direct and indirect pathways) and the molecular interactions of the T cell receptor (TCR) with the human leukocyte antigen (HLA)-peptide complex on antigen presenting cells (APCs) have stimulated research into peptide-based strategies of by: 3.

Organ transplantation has progressed with the comprehension of the major histocompatibility complex (MHC). It is true that the outcome of organ transplantation largely relies on how well rejection is managed.

It is no exaggeration to say that to be well acquainted with MHC is a shortcut to control rejection. In human beings, MHC is generally recognized as human leukocyte antigens (HLA).Author: Tsukasa Nakamura, Takayuki Shirouzu, Katsuya Nakata, Norio Yoshimura, Hidetaka Ushigome.

Direct allorecognition is a phenomenon unique to transplantation and is thought to result from the cross-reactivity of the host TCR to the donor MHC molecule Self-restricted, indirect Cited by: To understand the role of the direct pathway of allorecognition in rejection and the evolution of this response following transplantation, it is necessary to consider the anatomy of the direct alloresponse in vivo.

Anti‐donor alloreactive T cells derived from the naïve fraction of the recipients' T cell repertoire must be primed in lymphoid tissue.

tors in a murine model of skin transplantation [4]. The third pathway is the semidirect allorecognition. In this pathway, recipient APCs acquire intact allogeneic MHC–peptide complex from donor APCs by direct cell-to-cell contact or via release and uptake of small vesicles called exosomes, allowing CD8+ T-cell stimulation.

TheCited by: Donor cells release extracellular vesicles, including exosomes, after transplantation of allogeneic organs and tissues. Consequently, recipient APCs take up these exosomes and present donor MHC antigens on their surface (allo-MHC cross-dressing) thus, activating some alloreactive T cells via a mechanism called semi-direct pathway of by: 8.

allorecognition (Fig 2B) occurs in the secondary lymphatic system when donor proteins or peptides are processed by recipient APCs and presented to the TCR. In the transplant, indirect allorecognition occurs when recipient APCs process donor peptides and engage recipient lymphocytes by presenting those processed peptides.

The direct pathway of allor. The MHC is involved in the direct mechanism of allorecognition where T-cells recognize determinants on the donor MHC molecule-peptide complex displayed at the cell surface.Alloreactive T cells play a central role in transplantation: they are key mediators of tolerance, rejection, and GVHD.

Questions remain about the role of various allorecognition pathways in allograft rejection in vivo and about the mechanisms by which naive and memory T cells may become by:   There are also cases where the peptide changes structural characteristics of the MHC molecule and leads to recognition by certain T cell clones in a peptide-dependent rather than peptide-specific man17, Today, the two models of allorecognition may be seen as two extremes on a scale where MHC and peptide contribute in different degrees.